Exercise Capacity in HFpEF Not Impaired by Reduced Diastolic Filling Time


Utilizing chronotropic response as a reference, examine authors from Japan investigated the potential affect of exercise-induced coronary heart price on cardiac output reserve and train capability amongst a cohort of sufferers with coronary heart failure with preserved ejection fraction (HFpEF).

Neither train capability nor cardiac output reserve had been impaired in sufferers with coronary heart failure with preserved ejection fraction (HFpEF) following a bicycle train echocardiography and expired gasoline evaluation, regardless of diminished diastolic filling time, in response to examine findings printed in Journal of the American Coronary heart Affiliation.

“We sought to find out the affiliation between coronary heart price, diastolic filling time, hemodynamics, and train capability in HFpEF,” the authors wrote.

The 173 examine contributors had been divided into 2 teams: 66 had been within the group who had HFpEF and 107 had been within the non-HF cohort. They underwent train stress cardiography on the echocardiographic laboratory of Gunma College Hospital, Maebashi, Japan, between October 2019 and September 2021. The stress take a look at consisted of 20-W increments of three minutes every till subject-reported exhaustion. Management group contributors couldn’t have a cardiac-related reason for dyspnea.

Total whole median peak train workload was 33% decrease among the many HFpEF cohort vs the management group, at 40 (vary, 40-60) vs 60 (vary, 40-80) and imply train period was 13% shorter, at 532 (178) vs 614 (196) seconds. Nonetheless, imply respiratory change ratios had been related: 1.12 (0.15) vs 1.10 (0.17), respectively. Additional, when contemplating the workload carried out, effort and dyspnea median scores had been increased within the HFpEF cohort vs the management group: 0.32 (vary, 0.25-0.43) vs 0.25 (vary, 0.20-0.32) and 0.13 (vary, 0.08-0.18) vs 0.09 (vary, 0.05-0.13), respectively.

Sufferers within the HFpEF cohort had been older than controls (imply [SD] age, 74 [8] vs 63 [13] years), had the next price of hypertension (83% vs 66%), had quadruple the speed of β-blocker use (33% vs 7%), and had a diminished estimated glomerular filtration price (63 [23] vs 67 [21] mL/min/1.73 m2). As well as, their imply baseline E-wave and A-wave had been elevated in contrast with the management group:

  • E-wave: 74 (26) vs 63 (16) cm/s
  • A-wave: 91 (27) vs 76 (21) cm/s

On a scale of 0 to 60 W, overlap time regularly elevated for each teams concurrent with an increase in coronary heart price, with the management group numbers being barely increased than the HFpEF group in any respect factors (0, 20, 40, 60 W). This overlap time enhance indicated a shorter diastolic filling time.

In flip, throughout peak train, the upper coronary heart price in each teams had a optimistic correlation with increased cardiac output (r = 0.51; P < .0001) and oxygen consumption (r = 0.50; P < .0001). As well as, the shortened diastolic filling time had a optimistic correlation with increased cardiac output (r = 0.47; P < .0001), in addition to peak oxygen consumption (r = 0.38; P = .007).

There was additionally a optimistic relationship seen between longer overlap time and each mitral A velocity (r = 0.53; P < .0001) and left atrial booster pump pressure (r = 0.42; P < .0001).

“These information recommend that shortening the diastolic filling interval in tandem with elevated coronary heart price throughout train doesn’t restrict cardiac output reserve or train capability in sufferers with HFpEF,” the authors wrote. “Our information point out a compensatory mechanism for the discount within the diastolic filling interval by enhancing left atrial contractile operate.”

In addition they observe that as a result of latest analysis signifies β-blockers might worsen chronotropic response to cardiac output–limiting train and enhance left ventricular wall stress, the choice to cease their use amongst sufferers with diminished train capability and chronotropic incompetence ought to be investigated.

“Additional research are required to advance our understanding of the underlying pathophysiological mechanisms and to discover optimum remedy on this syndrome,” they concluded.


Kagami Okay, Obokata M, Harada T, et al. Diastolic filling time, chronotropic response, and train capability in coronary heart failure and preserved ejection fraction with sinus rhythm. J Am Coronary heart Assoc. Printed on-line June 29, 2022. doi:10.1161/JAHA.121.026009